New Treatments for Recurrent Glioblastoma

This study compares new drugs, relatlimab and nivolumab, with traditional chemotherapy for treating recurrent glioblastoma to see which is more effective and safer.

This study may be approprate for those with:Recurrent

Evaluating Safety and Efficacy of ABBV-101 for B-Cell Malignancies

The study evaluates a new drug, ABBV-101, for adults with certain B-cell cancers. It examines safety, effectiveness, and the movement of ABBV-101 through the body over about five years. Participants will have regular hospital visits for monitoring and tests.

This study may be approprate for those with:Relapsed / Refractory

Replimune | RPL-001-16 | IGNYTE

RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with nivolumab in adult subjects with advanced and/or refractory solid tumors, to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D), as well as to evaluate preliminary efficacy.

This study may be approprate for those with:Relapsed / Refractory

Study on UB-VV111 and Rapamycin for CD19+ B-cell Malignancies

This study tests a new treatment, UB-VV111, with or without Rapamycin in patients with certain returning B-cell cancers. It evaluates the safety and how well the treatment works over two years. Eligible participants must meet specific health criteria. Pregnant women and people with certain conditions cannot join.

This study may be approprate for those with:Relapsed / Refractory

Study on ABBV-383 for Relapsed or Refractory Multiple Myeloma

This study tests ABBV-383, a drug for relapsed/refractory multiple myeloma, focusing on safety and side effects. About 180 people will participate globally, receiving the drug by IV every 28 days for up to three years, with regular check-ups.

This study may be approprate for those with:Relapsed / Refractory

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors. 

This study may be approprate for those with:Newly Diagnosed Cancer

Comparing Effectiveness of Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma

This phase II trial compares mosunetuzumab to the usual treatment (rituximab) for improving survival in patients with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL).

This study may be approprate for those with:Relapsed / Refractory

Navtemadlin Add-on Study for Improved Myelofibrosis Treatment

This study checks if adding Navtemadlin to Ruxolitinib helps treat Myelofibrosis better, focusing on patients not fully responding to Ruxolitinib alone. Participants will initially use Ruxolitinib, then be randomly assigned extra treatment or a placebo. The study monitors changes in spleen size and symptoms over time.

This study may be approprate for those with:Recurrent

A Study of onCARlytics (CF33-CD19) in Combination With Blinatumomab in Adults With Advanced or Metastatic Solid Tumors

This clinical trial is a Phase I study to evaluate the safety and tolerability of onCARlytics (CF33-CD19) combined with blinatumomab in adults with advanced or metastatic solid tumors. It involves both intravenous and intratumoral administration of the treatment. The study is recruiting participants who have advanced solid tumors that have progressed after at least two prior treatments for their cancer.

This study may be approprate for those with:Metastatic Cancer

P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignancies

This clinical trial, sponsored by Poseida Therapeutics, is an open-label, Phase 1 study evaluating the safety of P-CD19CD20-ALLO1 CAR-T cells in adults with certain relapsed or refractory B cell malignancies. The study involves dose escalation to find a safe dosage and examines the treatment's safety and effectiveness over time. Participants will undergo lymphodepletion therapy before receiving the CAR-T cells. The trial aims to measure safety, adverse events, and responses to treatment, including survival rates and progression-free survival.

This study may be approprate for those with:Relapsed / Refractory

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer

Pembro or Observation

This study may be approprate for those with:Newly Diagnosed Cancer

Study Compares Treatments for Recurrent or Metastatic Cervical Cancer

The study tests a new drug, sacituzumab tirumotecan, against standard treatments for cervical cancer that has returned or spread. It aims to learn whether this new drug can help patients live longer. Participants must have tried previous treatments but still have growing cancer. Some medical conditions will exclude participation.

This study may be approprate for those with:Metastatic Cancer

Study on Treatment Combinations for Advanced Lung Cancer

This study is testing how well certain drug combinations work against advanced lung cancer with specific genetic mutations. Two different combinations are being tested: one is a mix of two drugs, amivantamab and lazertinib, and the other is amivantamab with chemotherapy. The study hopes to control cancer growth and improve survival.

This study may be approprate for those with:Metastatic Cancer

Study of Rilvegostomig vs. Pembrolizumab with Chemotherapy for Lung Cancer

This study compares rilvegostomig against pembrolizumab when taken with chemotherapy for treating advanced squamous NSCLC in patients whose tumors express PD-L1.

This study may be approprate for those with:Metastatic Cancer

Pancreatic Ductal- Met or unrectable

Gemcitabine/ Nab-Paclitaxel + CA-4948, must have had prior 5FU based therapy

This study may be approprate for those with:Metastatic Cancer

Testing RMC-6236 for Metastatic Pancreatic Cancer Treatment

This Phase 3 study tests RMC-6236 against standard chemotherapy in patients with metastatic pancreatic cancer who have already received treatment. It aims to see if the new drug improves survival rates and delays disease progression. Participants need to be 18 years or older and meet certain health criteria.

This study may be approprate for those with:Metastatic Cancer

Study of Ipatasertib with Chemoradiation for Head and Neck Cancer

This study investigates whether adding ipatasertib to standard chemo-radiation improves treatment outcomes for head and neck cancer. The goal is to find a safe dose that might offer better cancer control than existing therapies alone.

This study may be approprate for those with:Newly Diagnosed Cancer

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. 

This study may be approprate for those with:Newly Diagnosed Cancer

Study on Radiation Therapy for High-Risk Bone Metastases

This study compares the effects of radiation therapy plus usual care versus usual care alone on bone-related complications in cancer patients with certain high-risk bone metastases that are not causing symptoms.

Trial of Nadofaragene Firadenovec vs. Observation for Bladder Cancer

The study compares a new treatment called Nadofaragene Firadenovec with regular observation in people who have a specific type of bladder cancer. The key focus is on preventing the cancer from returning or getting worse.

This study may be approprate for those with:Metastatic Cancer

EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

This study will evaluate the safety and efficacy of intravesical administration of EG-70 in the bladder and its effect on bladder tumors in patients with NMIBC.

This study may be approprate for those with:Relapsed / Refractory

Comparing Dostarlimab vs Placebo After Chemoradiation for Head and Neck Cancer

This study tests if Dostarlimab helps prevent cancer from returning or spreading in patients with advanced head and neck cancer after chemoradiation. Participants must be newly diagnosed without distant cancer spread. It lasts up to 5 years.

This study may be approprate for those with:Newly Diagnosed Cancer

Study on Petosemtamab for Treated Head and Neck Cancer

This study tests Petosemtamab versus other treatments chosen by doctors on previously treated head and neck cancer patients. Its goal is to see if Petosemtamab improves outcomes for these patients.

This study may be approprate for those with:Recurrent

Study on New Treatments for Metastatic Non-Small Cell Lung Cancer

This study investigates two different methods of administering pembrolizumab for treating metastatic non-small cell lung cancer — one through an IV infusion, and the other via a subcutaneous injection. Researchers aim to compare how well these methods work and monitor patient responses over several months. Participants should have non-small cell lung cancer, and certain health conditions could exclude individuals from participating.

This study may be approprate for those with:Metastatic Cancer

Study on BMX-001 for Reducing Mouth Sores in Head and Neck Cancer Patients

This study explores if the drug BMX-001 can reduce painful mouth sores in patients undergoing chemoradiation therapy for head and neck cancer. By comparing it to a placebo, researchers aim to see if BMX-001 offers additional relief.

This study may be approprate for those with:Metastatic Cancer

Safety and Efficacy of REGN7075 and Cemiplimab in Cancer

This study is researching an investigational drug called REGN7075 by itself and in combination with cemiplimab with or without chemotherapy. The study is focused on patients with certain solid tumors that are in an advanced stage. 

This study may be approprate for those with:Metastatic Cancer

Trial for New Glioblastoma Treatment with Added Lomustine

This study tests if adding lomustine to usual therapy helps treat a specific type of brain cancer better. Participants will be randomly assigned treatment groups to compare effects on survival and tumor progression.

This study may be approprate for those with:Newly Diagnosed Cancer

Activity and Safety of Danvatirsen and Pembrolizumab in HNSCC (PEMDA-HN)

Open-label, Phase II, randomized, controlled study evaluating the efficacy and safety of danvatirsen in combination with pembrolizumab compared with pembrolizumab alone as first-line treatment of patients with recurrent/metastatic (R/M) HNSCC. Two-thirds of patients will be randomized to receive danvatirsen and pembrolizumab and one-third will be randomized to receive pembrolizumab alone

This study may be approprate for those with:Metastatic Cancer

CLL/SLL-Untreated and Previously Treated

LP-168 and Obinutuzumab

This study may be approprate for those with:Recurrent

Study of RAS Inhibitors in GI Tumors

This study evaluates new RAS inhibitors combined with standard or new treatments for patients with gastrointestinal cancers, including colorectal and pancreatic cancers. The focus is on safety, tolerability, and early antitumor effects. The study has three parts, each testing different drug combinations. Participants must be adults with certain cancer types and meet health criteria. Outcomes include monitoring adverse events, drug levels, and patient responses over time.

This study may be approprate for those with:Metastatic Cancer

Study on New Bladder Cancer Treatment Options

This study explores new treatment options for high-grade non-muscle invasive bladder cancer using a drug called nadofaragene firadenovec. Participants receive this treatment alone or combined with chemotherapy or immunotherapy to measure its effectiveness in reducing cancer recurrence.

This study may be approprate for those with:Metastatic Cancer

Study of Cemiplimab and Surgery for Advanced Skin Cancer

This study evaluates whether adding the immunotherapy drug cemiplimab to surgery improves treatment outcomes for patients with advanced, resectable skin cancer.

This study may be approprate for those with:Metastatic Cancer

Study on TEV-56278 for Treating Advanced Solid Tumors

This study tests the safety and effectiveness of TEV-56278, alone and with Pembrolizumab, in advanced solid tumors treatment. Participants will be involved for up to two years, receiving treatment and undergoing monitoring to assess drug safety and any anti-tumor activity.

This study may be approprate for those with:Metastatic Cancer

Study of Toripalimab With Chemotherapy for Nasopharyngeal Cancer

This study tests if a drug combo, including toripalimab, helps treat certain advanced nasopharyngeal cancers. Participants should not have had similar treatments before or foreign growths that are curable with other treatments. Researchers will assess benefits like tumor shrinkage.

This study may be approprate for those with:Metastatic Cancer

Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic HPV Negative Head and Neck SCC

The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer.

This study may be approprate for those with:Metastatic Cancer

A Study of DB-1311 in Advanced/​Metastatic Solid Tumors

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311 in subjects with advanced solid tumors.

This study may be approprate for those with:Metastatic Cancer

Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

This screening and multi-sub-study Phase 1b/2 trial will establish a method for genomic screening followed by assigning and accruing simultaneously to a multi-study "Master Protocol (BAML-16-001-M1)." The specific subtype of acute myeloid leukemia will determine which sub-study, within this protocol, a participant will be assigned to evaluate investigational therapies or combinations with the ultimate goal of advancing new targeted therapies for approval. The study also includes a marker negative sub-study which will include all screened patients not eligible for any of the biomarker-driven sub-studies.

This study may be approprate for those with:Newly Diagnosed Cancer

Comparing Two Radiation Therapies for Brain Cancer Spread from Other Body Parts

This study examines whether a longer duration of radiation therapy (called FSRS) is better than the usual shorter therapy (SRS) for people with certain cancers that have spread to the brain. It involves comparing how well each method works in preventing cancer from growing and the side effects experienced.

This study may be approprate for those with:Relapsed / Refractory

Comparing Treatments for Advanced Non-small Cell Lung Cancer

This study compares two drug combinations for treating advanced lung cancer. It aims to see which treatment helps patients live longer and whether they can manage side effects.

This study may be approprate for those with:Recurrent

Study of V940 Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants With Non-small Cell Lung Cancer

This study aims to compare the effectiveness of V940 plus pembrolizumab versus a placebo plus pembrolizumab in treating patients with certain stages of lung cancer that have been surgically removed. Key outcomes include time until cancer recurrence, overall survival, and quality of life. Participants must have had complete tumor removal and prior chemotherapy. The study will follow participants for up to 12 years to monitor these outcomes.

This study may be approprate for those with:Newly Diagnosed Cancer

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/​11 Mutations or PRKC Fusions

This is a Phase 1/2, multi-center, open-label basket study designed to evaluate the safety and anti-tumor activity of IDE196 in patients with solid tumors harboring GNAQ or GNA11 (GNAQ/11) mutations or PRKC fusions, including metastatic uveal melanoma (MUM), cutaneous melanoma, colorectal cancer, and other solid tumors.

This study may be approprate for those with:Metastatic Cancer

Higher Dose Radiation Therapy for Advanced Pancreatic Cancer Trial

This study tests if higher doses of radiation therapy help people with advanced pancreatic cancer live longer after initial chemotherapy. It compares this treatment to regular care options like continued chemotherapy or observation and measures survival and quality of life impacts.

This study may be approprate for those with:Metastatic Cancer

Blood Test for ctDNA in Guiding Immunotherapy After Bladder Cancer Surgery

This study is testing if a blood test that checks for DNA from bladder cancer cells can guide the use of immunotherapy after surgery. It aims to find out if this approach can help prevent the cancer from coming back. The study will involve patients who have had bladder cancer surgery and will look at how well additional treatments work based on the blood test results.

This study may be approprate for those with:Newly Diagnosed Cancer

De-Escalation of Breast Radiation Trial for Hormone Sensitive

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

This study may be approprate for those with:Newly Diagnosed Cancer

ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/​PD-L1 Inhibitors (PRESERVE-003)

The goal of this Phase 3 clinical trial is study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patients with metastatic non-small cell lung cancer who have disease progressed on anti-PD-1/PD-L1 antibody based therapy.

This study may be approprate for those with:Metastatic Cancer

Comparing Anitocabtagene Autoleucel to Standard Therapy for Multiple Myeloma

This study compares a new drug, anitocabtagene autoleucel, with standard treatments for multiple myeloma that's difficult to treat. Participants need to have tried 1-3 other treatments previously. The study aims to see if the new drug is better at stopping the disease from getting worse.

This study may be approprate for those with:Relapsed / Refractory

Testing Abemaciclib with 5-Fluorouracil for Metastatic Colorectal Cancer

This study tests a new combination of cancer drugs for people with advanced colorectal cancer that hasn't responded to other treatments. It aims to find a safe dose that can be tolerated by most patients while seeing if the drug combo is effective in treating the cancer.

This study may be approprate for those with:Metastatic Cancer

Study of Sapanisertib and Serabelisib with Paclitaxel for Endometrial Cancer

This study tests a combination of drugs with a special diet in patients with advanced endometrial cancer. It seeks to find out if this new treatment improves patient outcomes and understand any side effects. To join, patients must have failed previous treatments like chemotherapy. Participants must fit specific criteria, including having certain genetic markers, and they should not have other major health issues.

This study may be approprate for those with:Relapsed / Refractory

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together before limited surgery? If radiation therapy is not given, is quality of life better?

This study may be approprate for those with:Newly Diagnosed Cancer

A Study of NX-5948 in Adults With Relapsed/​Refractory B-cell Malignancies

This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of NX-5948 in patients with advanced B-cell malignancies.

This study may be approprate for those with:Relapsed / Refractory

Testing the Addition of BMS-986016 (Relatlimab) to Immunotherapy for Recurrent or Metastatic Nasopharyngeal Cancer

This clinical trial, led by the National Cancer Institute, is studying the addition of the drug relatlimab to the usual immunotherapy treatment for patients with recurrent or metastatic nasopharyngeal cancer. The trial aims to see if adding relatlimab to nivolumab can improve the time patients live without their cancer getting worse. Participants receive initial treatment with chemotherapy and immunotherapy, then are randomized to continue with nivolumab alone or with the addition of relatlimab.

This study may be approprate for those with:Recurrent

Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

This Phase III trial will examine the efficacy of computerized cognitive training methods on perceived cognitive impairment in breast cancer survivors.

This study may be approprate for those with:Newly Diagnosed Cancer

Study on Heated Chemotherapy and Niraparib for Advanced Ovarian Cancer

This study investigates whether heated chemotherapy applied during surgery, followed by the drug niraparib, improves outcomes for patients with advanced ovarian, primary peritoneal, and fallopian tube cancers. Two groups will be compared: one receiving heated chemotherapy and the other not. All patients will receive standard chemotherapy and then niraparib after surgery.

This study may be approprate for those with:Newly Diagnosed Cancer

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies

This is a phase I, multi-center, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and clinical activity of LP-168 in subjects with relapsed or refractory B-cell malignancies. LP-168 is a small molecule inhibitor.

This study may be approprate for those with:Relapsed / Refractory

Testing CHS-114 in People with Advanced Solid Tumors

This study is testing a new treatment, CHS-114, for people with difficult-to-treat solid tumors. It checks if the treatment is safe and helpful and looks at how patients respond. There are three parts: testing different doses of the treatment, saw about its effects alone, and combined with another drug.

This study may be approprate for those with:Relapsed / Refractory

Testing the Addition of the Drug Apalutamide to Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer

This phase III trial studies whether adding apalutamide to the usual treatment improves outcome in patients with lymph node positive prostate cancer after surgery.

This study may be approprate for those with:Newly Diagnosed Cancer

Investigating NBTXR3 and Radiation for Head and Neck Cancer

This study looks at how effective a new treatment, NBTXR3 combined with radiation therapy, is compared to standard treatment for elderly patients with advanced head and neck cancer who cannot have chemotherapy.

This study may be approprate for those with:Metastatic Cancer

Advanced R/R solid tumors

TTX-080 monotherapy (HLA-G inhibitor) +/- pembrolizumab or cetuximab

This study may be approprate for those with:Relapsed / Refractory

Study on NXC-201 CAR-T for Relapsed Light Chain Amyloidosis

This study tests a treatment known as NXC-201 CAR-T for patients with relapsed or hard-to-treat AL amyloidosis. It will check how safe and helpful the treatment is over a period of two years.

This study may be approprate for those with:Relapsed / Refractory

Adding SNDX-5613 to the Standard Chemotherapy Treatment for Newly Diagnosed Patients With Acute Myeloid Leukemia

This phase Ib trial tests the safety, side effects, and best dose of SNDX-5613 when given in combination with the standard chemotherapy treatment (daunorubicin and cytarabine) in treating patients with newly diagnosed acute myeloid leukemia that has changes in the NPM1 gene or MLL/KMT2A gene.

This study may be approprate for those with:Newly Diagnosed Cancer

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodyspla

This phase II trial tests whether decitabine and cedazuridine (ASTX727) in combination with venetoclax work better than ASTX727 alone at decreasing symptoms of bone marrow cancer in patients with chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) with excess blasts.

This study may be approprate for those with:Newly Diagnosed Cancer

Comparing ABBV-383 to Standard Treatments in Relapsed Multiple Myeloma

This study will compare a new medicine, ABBV-383, to current treatments for people with relapsed multiple myeloma, aiming to provide better management and outcomes for the disease.

This study may be approprate for those with:Relapsed / Refractory

OBI-3424 in Relapsed T-ALL: Phase II Trial Study

This phase II trial studies how well OBI-3424 works in treating patients with T-cell acute lymphoblastic leukemia that has come back (relapsed) or does not response to treatment (refractory).

This study may be approprate for those with:Relapsed / Refractory

Study of Selinexor and Temozolomide for Recurrent Brain Tumors

This study tests if combining a new drug, selinexor, with usual chemotherapy can better treat recurrent brain tumors than chemotherapy alone.

This study may be approprate for those with:Recurrent

Study on Teclistamab and Talquetamab for Treating Multiple Myeloma

This study tests new medication combos, teclistamab and talquetamab, for treating newly diagnosed multiple myeloma patients who can't have a stem cell transplant yet. It compares their effectiveness against current standard treatments over several years.

This study may be approprate for those with:Newly Diagnosed Cancer

Study of AJ1-11095 for Untreatable Myelofibrosis Patients

This study tests the safety and effectiveness of a new drug, AJ1-11095, on myelofibrosis patients who haven't responded to previous treatments. Participants will receive the drug to find out the safest dose.

This study may be approprate for those with:Relapsed / Refractory

Study of BNT327 and Chemotherapy for Lung Cancer Treatment

This study is testing a new drug called BNT327 with chemotherapy in adults with a type of lung cancer known as non-small cell lung cancer. It's looking at whether this treatment combo can help patients live longer and experience fewer tumor growths. The study involves regular visits over a period of up to 5 years.

This study may be approprate for those with:Metastatic Cancer

Testing Radiation Plus Immunotherapy for Metastatic Renal Cell Cancer

The study looks at whether adding stereotactic radiation to immunotherapy helps patients with advanced kidney cancer that can't be removed by surgery. The study aims to improve how well treatments work together against cancer progression.

This study may be approprate for those with:Metastatic Cancer

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma (MM)

Phase 1 study comprised of open-label, dose escalation, multiple cohorts of P-BCMA-ALLO1 allogeneic T stem cell memory (Tscm) CAR-T cells in subjects with relapsed / refractory Multiple Myeloma (RRMM).

This study may be approprate for those with:Relapsed / Refractory

A Phase 1/​2 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway

This clinical trial is investigating the drug MRTX0902 for treating advanced solid tumors with specific mutations. The study is in Phase 1/2 and is currently recruiting participants. It aims to evaluate the safety, tolerability, and effectiveness of MRTX0902, both alone and in combination with another drug, adagrasib. The trial includes patients with cancers like non-small cell lung cancer and colorectal cancer who have certain genetic mutations. Participants must have tumors that can't be surgically removed and have no other treatment options.

This study may be approprate for those with:Metastatic Cancer

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several genes have been found to be altered or mutated in brain metastases such as NTRK, ROS1, CDK, PI3K, or KRAS G12C. Medications that target these genes such as abemaciclib, paxalisib, entrectinib and adagrasib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Genetic testing may help doctors tailor treatment for each mutation.

This study may be approprate for those with:Metastatic Cancer

Study of IMPT-314 in R/​R Aggressive B-cell NHL

This is a Phase 1/2, multi-center, open-label study evaluating the safety and efficacy of IMPT-314, a bispecific chimeric antigen receptor (CAR) targeting cluster of differentiation (CD)19 and CD20 in participants with aggressive B-cell NHL. Three cohorts of participants will be enrolled: 1) CAR T naïve after at least two or more prior lines of treatment, 2) CAR T experienced and 3) refractory disease or relapse within one year of first line therapy.

This study may be approprate for those with:Relapsed / Refractory

A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma

This is a Phase 2 study to evaluate the clinical activity and safety of ZN-c3 (azenosertib) in adult women with recurrent or persistent uterine serous carcinoma (USC).

This study may be approprate for those with:Recurrent

Study on New Treatment for Recurrent Ovarian Cancer

This study tests a new drug for ovarian cancer that has returned. It compares the new treatment's safety and effectiveness with standard care to see if patients live longer without their disease getting worse. Patients will be closely monitored for side effects.

This study may be approprate for those with:Relapsed / Refractory

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery

This phase III trial compares the effect of adding surgery to a standard of care immunotherapy-based drug combination versus a standard of care immunotherapy-based drug combination alone in treating patients with kidney cancer that has spread to other places in the body (metastatic).

This study may be approprate for those with:Newly Diagnosed Cancer

Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer.

This study may be approprate for those with:Newly Diagnosed Cancer

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)

This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.

This study may be approprate for those with:Newly Diagnosed Cancer

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug in High-Risk Head and Neck Cancer

This phase II/III trial studies how well radiation therapy works when given together with cisplatin, docetaxel, cetuximab, and/or atezolizumab after surgery in treating patients with high-risk stage III-IV head and neck cancer the begins in the thin, flat cells (squamous cell)

This study may be approprate for those with:Newly Diagnosed Cancer

Efficacy and Safety of Adjuvant in Patients With Resected Pancreatic Ductal Adenocarcinoma

The purpose of this study is to evaluate the efficacy and safety of adjuvant autogene cevumeran plus atezolizumab and modified leucovorin, 5-fluorouracil (5-FU), irinotecan, and oxaliplatin (mFOLFIRINOX) versus mFOLFIRINOX alone in participants with resected pancreatic ductal adenocarcinoma (PDAC) who have not received prior systemic anti-cancer treatment for PDAC and have no evidence of disease after surgery.

This study may be approprate for those with:Newly Diagnosed Cancer

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

The purpose of the study is to compare two surgical procedures and their ability to decrease the risk of developing ovarian cancer for pre-menopausal women with BRCA1 mutations. Participants will choose to undergo surgery to remove the fallopian tubes only and plan to have the ovaries removed in the future (BLS group) or remove the fallopian tubes and ovaries at the same time (BSO group).

This study may be approprate for those with:Newly Diagnosed Cancer

A Phase 1B/​2 Study of RP1 in Solid Organ Transplant Patients With Advanced Cutaneous Malignancies (ARTACUS)

This Phase 1B/2 study is a multicenter, open-label, study of RP1 to investigate the (a) objective response rate, in addition to (b) safety and tolerability of RP1 for the treatment of advanced cutaneous malignancies in up to 65 evaluable organ transplant recipients.

This study may be approprate for those with:Metastatic Cancer

Testing PARP Inhibitors Before Prostate Cancer Surgery

This study examines a drug combination given before prostate cancer surgery to try to shrink the tumor in men with specific high-risk gene changes. Researchers will observe the effect on the tumor size and watch for side effects.

This study may be approprate for those with:Newly Diagnosed Cancer

Study on IOV-4001 for Advanced Melanoma and NSCLC

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC).

This study may be approprate for those with:Metastatic Cancer

Study of MK-1084 and Pembrolizumab for Lung Cancer

This study explores the combination of MK-1084 and pembrolizumab for treating a specific type of lung cancer. It checks if this duo is better than current options by increasing survival rates and slowing cancer progression.

This study may be approprate for those with:Newly Diagnosed Cancer

Testing Venetoclax for Relapsed Hairy Cell Leukemia

This study examines whether venetoclax is effective in treating patients with relapsed hairy cell leukemia. It involves taking the medication daily and regular check-ups for up to 19 cycles.

This study may be approprate for those with:Relapsed / Refractory

Study on BAY 2927088 for Lung Cancer with HER2 Mutations

This study tests BAY 2927088 for treating advanced lung cancer with HER2 mutations, comparing it to current treatments. It focuses on safety and effectiveness through various health checks and scans over up to four years.

This study may be approprate for those with:Metastatic Cancer

Combining Iadademstat with Immunotherapy for Advanced Lung Cancer

Researchers are studying whether adding a new drug, iadademstat, to existing immunotherapies can better control small cell lung cancer. The study involves repeated cycles of treatment and aims to find out if this combination can keep the cancer stable longer than current treatments alone.

This study may be approprate for those with:Newly Diagnosed Cancer

REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation (REDEL)

To determine the efficacy of reduced elective nodal radiation in anal cancer patients undergoing chemoradiation in reducing toxicity compared to standard nodal irradiation.

This study may be approprate for those with:Newly Diagnosed Cancer

Testing Ado-Trastuzumab Emtansine Compared to the Usual Treatment for Salivary Gland Cancer

This phase II trial tests whether ado-trastuzumab emtansine works to shrink tumors in patients with HER2-positive salivary gland cancer that has come back (recurrent), spread to other places in the body (metastatic), or cannot be removed by surgery (unresectable).

This study may be approprate for those with:Metastatic Cancer

Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma

This phase II trial studies the effect of duvelisib or CC-486 and usual chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone in treating patients with peripheral T-cell lymphoma.

This study may be approprate for those with:Newly Diagnosed Cancer

A Study of LP-118 in Patients With Advanced Tumors

This is a phase I, multi-center, open-label, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and clinical activity of LP-118 in patients with advanced malignancies, including solid tumors and lymphomas. LP-118 is a BCL-2/BCL-XL small molecule inhibitor.

This study may be approprate for those with:Relapsed / Refractory

Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.

This study may be approprate for those with:Metastatic Cancer

Study of Ficerafusp Alfa and Pembrolizumab for Head and Neck Cancer

This clinical trial is testing a new drug combination, ficerafusp alfa and pembrolizumab, to treat certain head and neck cancers. Participants will either receive the new combination or a placebo, and researchers aim to assess its safety and effectiveness over several years.

This study may be approprate for those with:Newly Diagnosed Cancer

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

This is a prospective, open-label, multi-cohort, non-randomized, multicenter phase 2 study evaluating LN-145 in patients with metastatic non-small-cell lung cancer

This study may be approprate for those with:Metastatic Cancer

ZEN003694 with Capecitabine for Advanced Solid Tumors

This phase I trial tests the safety, side effects, and best dose of ZEN003694 in combination with the usual treatment with capecitabine in treating patients with cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or cannot be removed by surgery (unresectable) and that it has progressed on previous standard treatment.

This study may be approprate for those with:Metastatic Cancer

Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced).

This study may be approprate for those with:Metastatic Cancer

Testing a New Drug SGR-3515 for Advanced Solid Tumors

This study tests a new drug, SGR-3515, for people with advanced solid tumors. It checks its safety, how well it's tolerated, and its potential effectiveness. Participants need to have a specific health profile and not have certain other conditions or recent treatments.

This study may be approprate for those with:Newly Diagnosed Cancer

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

This is a Phase 2/3, multi-arm, multi-stage, open-label study of human leukocyte antigen (HLA)-A*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotinib or investigator's choice of treatment (pembrolizumab, ipilimumab + nivolumab, or dacarbazine).

This study may be approprate for those with:Metastatic Cancer

Study of ZE50-0134 for Chronic Lymphocytic Leukemia and Lymphomas

This study tests ZE50-0134 in adults with certain blood cancers like chronic lymphocytic leukemia that have not responded to standard treatments. Researchers aim to find a safe dose level and evaluate effectiveness over several weeks through different stages of testing. Participants should not have certain serious health conditions.

This study may be approprate for those with:Relapsed / Refractory

Selinexor for Maintenance in Advanced Endometrial Cancer

The purpose of this study is to evaluate the efficacy and safety of selinexor as a maintenance treatment in patients with p53 wt endometrial carcinoma (EC), who have achieved a partial response (PR) or complete response (CR) (per Response Evaluation Criteria in Solid Tumors version 1.1 [RECIST v 1.1]) after completing at least 12 weeks of platinum-based therapy.

This study may be approprate for those with:Relapsed / Refractory

Pembrolizumab Study for Non-Small Cell Lung Cancer Treatment

This study is examining if adding the drug V940 to pembrolizumab helps prevent non-small cell lung cancer from returning after surgery. Participants must meet specific health criteria and cannot have certain prior treatments or conditions. The research will assess various health outcomes like survival and quality of life over a period that could last up to about 129 months.

This study may be approprate for those with:Recurrent

Trial of DB-1305 for Advanced Solid Tumors

This study is testing a new drug called DB-1305 in people with advanced solid tumors to find the best dose and check for side effects. Participants must be adults whose tumors haven't responded to other treatments. They will need regular visits over treatment cycles.

This study may be approprate for those with:Metastatic Cancer

ECOG ACRIN

This clinical trial, conducted by the National Cancer Institute, is testing treatments for adults newly diagnosed with BCR-ABL-positive acute lymphoblastic leukemia. It compares the effects of standard chemotherapy and steroids with a tyrosine kinase inhibitor (TKI) to the same regimen plus blinatumomab, a drug that may help stop cancer cell growth. The study aims to determine if the combination therapy improves overall survival and reduces residual disease. It also assesses the side effects and outcomes for patients who undergo different treatment paths. The trial is currently recruiting. Participants must be 18 to 75 years old and meet specific health criteria.

This study may be approprate for those with:Newly Diagnosed Cancer

Low-Dose Tamoxifen for Early-Stage Breast Cancer Study

This research compares a low dose of tamoxifen with standard hormone therapies to treat early-stage breast cancer in post-menopausal women, checking if it's as effective in preventing recurrence.

This study may be approprate for those with:Newly Diagnosed Cancer

Bevacizumab with or without Mirvetuximab in Ovarian, Fallopian Tube, or Peritoneal Cancer

GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.

This study may be approprate for those with:Recurrent

PDO Models for Preclinical Testing

UCCI-PDO-18-01 | University of Cincinnati Cancer Institute

This study may be approprate for those with:Newly Diagnosed Cancer

Testing New Treatment for Residual Cancer in B-cell Lymphoma Patients

This study tests a new treatment called cema-cel for adults with large B-cell lymphoma who show minimal residual disease after initial therapy. It aims to compare this treatment's effectiveness and safety against standard observation post-treatment.

This study may be approprate for those with:Newly Diagnosed Cancer

Testing LY3962673 in KRAS G12D-Mutant Solid Tumors

This study examines the safety and effectiveness of the drug LY3962673 for treating cancers with the KRAS G12D mutation. This includes certain types of pancreatic, lung, and colon cancers. The study will explore how well the drug works alone and alongside other treatments over a period of five years.

This study may be approprate for those with:Metastatic Cancer

Letrozole Study in Recurrent High Grade Gliomas

Gliomas- Letrozole+Standard Therapy

This study may be approprate for those with:Recurrent

Durvalumab With Gemcitabine and Cisplatin for the Treatment of High-Risk Resectable Liver Cancer Before Surgery

This phase II trial tests how well giving durvalumab with standard chemotherapy, gemcitabine and cisplatin, before surgery works in treating patients with high risk liver cancer (cholangiocarcinoma) that can be removed by surgery (resectable).

This study may be approprate for those with:Newly Diagnosed Cancer

Evaluating Safety of ABBV-525 in B-Cell Cancer Treatments

This study is testing a new drug, ABBV-525, for safety and effectiveness in treating certain B-cell cancers. Participants will receive different doses to see how the drug affects their disease and overall health. The study will take place over several months with regular visits to medical centers.

This study may be approprate for those with:Relapsed / Refractory

Trial of BNT113 and Pembrolizumab for HPV16+ Head and Neck Cancer

This study looks into a new treatment approach using BNT113 and pembrolizumab for head and neck cancer linked to HPV16. Patients' safety, response rates, and overall survival will be compared between those getting the combined treatment versus standard pembrolizumab treatment alone.

This study may be approprate for those with:Metastatic Cancer

Study of PF-07934040 for Advanced Tumors with KRAS Gene Mutations

This study tests a new cancer drug, PF-07934040, for people with advanced tumors having KRAS mutations. Participants will take this drug alone or with other therapies to see its safety and effectiveness. The study lasts up to four years, with regular clinic visits.

This study may be approprate for those with:Relapsed / Refractory

Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

The purpose of this study is to compare any good or bad effects of using pembrolizumab (an experimental drug) and radiation therapy (RT), compared to using cisplatin chemotherapy and radiation therapy (RT) in the treatment of patients with head and neck squamous cell carcinoma (HNSCC).

This study may be approprate for those with:Newly Diagnosed Cancer

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA SCC of the Head and Neck

This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IVA squamous cell carcinoma of the head and neck and disruptive p53 mutations who have undergone surgery.

This study may be approprate for those with:Newly Diagnosed Cancer

Study of GIM-531 for Advanced Solid Tumors

This study is testing a new drug called GIM-531 for people with advanced solid tumors. They want to know if it's safe and works well, especially for those who haven't responded to other treatments. Participants must have advanced cancer and cannot have certain medical conditions.

Testing New Drug Combo for Treating Acute Myeloid Leukemia

This study tests if a combination of three drugs can safely treat newly diagnosed AML patients. Researchers seek to find the safest dose and see how well this drug combo helps fight leukemia.

This study may be approprate for those with:Recurrent

Study of Isatuximab, Carfilzomib, and Dexamethasone for Multiple Myeloma

This study looks at a new treatment combination for people with multiple myeloma not responding to previous treatments. Using isatuximab, carfilzomib, and dexamethasone, it aims to find out if this combo is effective and how it affects patients.

This study may be approprate for those with:Relapsed / Refractory

Testing a New Combo Therapy for Relapsed Aggressive B-cell Lymphoma

This study is testing a combination of 5 drugs—venetoclax, ibrutinib, prednisone, obinutuzumab, and Revlimid—called ViPOR, to see if it is effective in treating patients with certain types of aggressive B-cell lymphoma that have come back or not responded to treatment.

This study may be approprate for those with:Relapsed / Refractory

Study of CBX-12 for Treating Hard-to-Treat Colorectal Cancer

This study tests CBX-12 for hard-to-treat colorectal cancer that has spread and no longer responds to current drugs. The trial evaluates if CBX-12 is better than standard treatments at stopping cancer growth without significant side effects, requiring treatment every 21 days.

This study may be approprate for those with:Metastatic Cancer

Exploring Mindfulness Apps for Breast Cancer Survivors

This study investigates if digital mindfulness methods help younger women who survived breast cancer manage depression. It compares a live online program to a self-paced app to find the best solution for improving mental health.

This study may be approprate for those with:Newly Diagnosed Cancer

Testing Rina-S Effectiveness for Platinum-Resistant Ovarian Cancer

This study tests whether Rina-S works better than standard chemotherapy against ovarian cancer that's resistant to platinum treatments. Participants get either Rina-S or a standard therapy, with all receiving active treatment—no placebo. The goal is to see if it helps patients live longer without their cancer getting worse.

This study may be approprate for those with:Relapsed / Refractory

FlowTriever vs Anticoagulation for Pulmonary Embolism

The PEERLESS II Study is a clinical trial by Inari Medical comparing the FlowTriever System plus anticoagulation with anticoagulation alone for treating intermediate-risk acute pulmonary embolism (PE). This trial is randomized and seeks to find out which treatment better prevents clinical deterioration, hospital readmission, and other health issues related to PE. Participants must be 18 or older and meet specific health criteria. The study is currently recruiting and aims to improve treatment options for PE patients.